Protein Modification Reagents
Medchemexpress LLC Pomalidomide-PEG4-C2-NH2 | 2225940-52-1 | 95.11% | 492.52 | 2 G
Pomalidomide-PEG4-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a 4-unit PEG linker used in PROTAC technology. It is for research use only and not sold to patients.
- Appearance: solid
- Color: light yellow to yellow
- Shipping: room temperature in continental US; may vary elsewhere.
- Storage: powder -20°C for 3 years, 4°C for 2 years. The compound is unstable in solutions, so freshly prepared solutions are recommended.
- Target: cereblon
- Related classifications: cancer, cancer targeted therapy, PROTAC E3 ligase ligand-linker conjugates.
- Usage: for research use only. We do not sell to patients.
Medchemexpress LLC Fluorescein-PEG4-acid | 1807518-76-8 | 96.3% | 654.68 | 25 MG
Fluorescein-PEG4-acid is a PEG-based PROTAC linker. It can be used in the synthesis of PROTACs, which are compounds containing two different ligands connected by a linker. One ligand is for an E3 ubiquitin ligase and the other is for the target protein, exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
Medchemexpress LLC Vh285-peg4-c4-cl | 1799506-07-2 | ≥98.0% | 799.42 | 10 MG
VH285-PEG4-C4-Cl is a conjugate of ligands for E3 and 16-atom-length linker. The connector of the linker is a halogen group. It incorporates a VH285 based VHL ligand and an alkyl/ether-based linker. It is a highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM. It is able to induce 90% degradation of GFP-Halotag at 625 nM and binds to VHL with an IC50 of 0.54 μM.
- Functions as a conjugate of ligands for E3 and a 16-atom-length linker.
- Incorporates a VHL ligand and an alkyl/ether-based linker.
- Highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM.
- Able to induce 90% degradation of GFP-Halotag at 625 nM.
- Binds to VHL with an IC50 of 0.54 μM.
- Induces nearly complete knockdown of HaloTag7-ERK1 and HaloTag7-MEK1 at 500 nM.
![Medchemexpress LLC Acetic acid, 2-[(18-chloro-3,6,9,12-tetraoxaoctadec-1-yl)oxy]- | 1799506-30-1 | 98.0% | 370.87 | 250 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000439158-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC Acetic acid, 2-[(18-chloro-3,6,9,12-tetraoxaoctadec-1-yl)oxy]- | 1799506-30-1 | 98.0% | 370.87 | 250 MG
Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) is a PEG-based PROTAC linker designed for the synthesis of chloroalkane-containing PROTACs, also known as HaloPROTACs. PROTACs function by utilizing the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker.
- Used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs).
- Facilitates selective degradation of target proteins via the ubiquitin-proteasome system.
Medchemexpress LLC DSPE-PEG-Maleimide | 1612754-08-1 | 100.0% | 2000 | 50 MG
DSPE-PEG-Maleimide (MW 2000) is a functional lipid component and a thiol-reactive crosslinker. It undergoes Michael addition with the thiol groups of thiolated or cyclic RGD peptides to form stable thioether bonds and DSPE-PEG (2000)-RGD. This product is applicable to research on drug delivery.
- Functional lipid component
- Thiol-reactive crosslinker
- Undergoes Michael addition with thiol groups
- Forms stable thioether bonds
- Forms DSPE-PEG (2000)-RGD with thiolated or cyclic RGD peptides
- Applicable to research on drug delivery
(=O)OCCNC(=O)OCCOCCNC(=O)OC1CCC\C=C\CC1)OC(=O)CCCCCCCCCCCCCCCCC | 25mg | 795361530](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC2818689.JPG-250.jpg)
eMolecules DSPE-PEG-TCO, MW 2,000 | Broadpharm | | | 1031.404 | C55H103N2O13P | 95.000 | CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCNC(=O)OCCOCCNC(=O)OC1CCC\C=C\CC1)OC(=O)CCCCCCCCCCCCCCCCC | 25mg | 795361530
DSPE-PEG-TCO, MW 2,000 | Broadpharm | | | 1031.404 | C55H103N2O13P | 95.000 | CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCNC(=O)OCCOCCNC(=O)OC1CCC\C=C\CC1)OC(=O)CCCCCCCCCCCCCCCCC | 25mg | 795361530
Broadpharm Methyltetrazine-amine HCl salt | 1345955-28-3 | MFCD30748954 | 25mg
Methyltetrazine-amine HCl salt | Putity: 95% | MW: 201.2 | 1345955-28-3 | MFCD30748954 | 25mg
Cayman Chemical BIOnT PROTAC Fragmnt lbrar 1mg
Customers are supplied with the following data package for EAch fragment purchases: • Aqueous buffer 1H NMR raw data file • Structures and physiochemical properties in an sd file • SPR Clean Screen results The parameters used in the design of the library are: • Heavy atoms ≤ 16 • clogP ≤ 3 • Hydrogen bond donors ≤ 1 • Hydrogen bond acceptors ≤ 3 • tPSA ≤ 60 • Rotatable bonds ≤ 3
eMolecules Broadpharm / m-PEG48-Mal / 100mg / 279709388 / BP-22752 / 98.000 / 88504-24-9 / MFCD21363232 / 2296.723 / C104H202N2O51
Broadpharm / m-PEG48-Mal / 100mg / 279709388 / BP-22752 / 98.000 / 88504-24-9 / MFCD21363232 / 2296.723 / C104H202N2O51
Bioworld D(+) Galactose, 500 g
An monosaccharidic aldo hexose potentially useful in aging studies. Specifications:High Purity GradeSpecific Rotation (2% water): 79 - 81°Appearance: White PowderBoiling Point : 410.8 °CDensity : 1.5 g/cm3HS Code : 29400090Melting Point: 168-170 °CRTECS Number: LW5490000
![eMolecules Broadpharm / DBCO-PEG24-Maleimide / 25mg / 686678589 / BP-25731 / / / [null] / 1555.811 / C76H122N4O29](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
eMolecules Broadpharm / DBCO-PEG24-Maleimide / 25mg / 686678589 / BP-25731 / / / [null] / 1555.811 / C76H122N4O29
Broadpharm / DBCO-PEG24-Maleimide / 25mg / 686678589 / BP-25731 / / / [null] / 1555.811 / C76H122N4O29
Med Vet International Timolol Maleate (Generic Timoptic) Solution, 0.5%, 15mL
VET LICENSE NEEDS TO BE PROVIDED IN 3-4 BUSINESS DAYS OR ORDER WILL BE CANCELLED
Timolol Maleate is a generic version of Timoptic. Ophthalmic Timolol is in a class of medications called beta-blockers. It is an ophthalmic solutions that is used to decrease pressure in the eye.
Medchemexpress LLC Biotin-PEG11-SH | 1650579-23-9 | 98.0% | 788.02 | C34H65N3O13S2 | 5 MG
BIOTIN-PEG11-SH is a biotinylation reagent containing an 11-unit polyethylene glycol spacer and a terminal thiol group. It is used to introduce a biotin tag onto proteins and other thiol-reactive biomolecules; the PEG spacer improves solubility and reduces steric hindrance to enable efficient labeling in biochemical and proteomic workflows.
- Terminal thiol group for thiol-specific conjugation.
- Peg11 spacer improves solubility and reduces steric hindrance.
- High purity (98.0%).
- Soluble in DMSO at concentrations ≥100 mg/mL.
- Solid form, recommended storage at -20 °C under nitrogen.
- Intended for research use in protein biotinylation and labeling applications.
Medchemexpress LLC DSPE-PEG carboxylic acid (sodium) | 1403744-37-5 | 2000 (average) | (C2H4O)nC45H86NO12P.Na | 5 MG
DSPE-PEG carboxylic acid (sodium), MW 2000 is a polyethylene glycol-conjugated phospholipid with a terminal carboxylate (sodium salt). It is used as a PEG-lipid component for formulating liposomes and nanoparticle drug delivery systems to improve circulation time, stability, and surface functionalization.
- PEG-lipid with terminal carboxylate (sodium salt) enabling conjugation and surface modification.
- Average molecular weight approximately 2000, suitable for PEGylation and stealth coatings.
- Improves liposome circulation time and colloidal stability.
- Enhances targeting potential and cellular uptake when formulated into nanoparticles.
- Solid, white to off-white form for convenient handling and storage.